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Adenium obesum is grown as a houseplant in temperate and tropical regions. Numerous hybrids have been developed. Adeniums are appreciated for their colorful flowers and unusual thick caudices. They can be grown for many years in a pot and are commonly used for bonsai.

As a traditional medicine in Africa, the Desert Rose is used for its antimicrobial, anticancer, antioxidant and antiviral properties. It is also known to be effective against venereal diseases, muscle and joint pains, skin diseases, ulcers and heart problems